Prevention of surgical site infection in lower limb skin lesion excisions with single dose oral antibiotic prophylaxis: a prospective randomised placebo-controlled double-blind trial

OBJECTIVES To determine the effectiveness of a single perioperative prophylactic 2 g dose of cephalexin in preventing surgical site infection (SSI) following excision of skin lesions from the lower limb. DESIGN Prospective double-blinded placebo-controlled trial testing for difference in infection rates. SETTING Primary care in regional North Queensland, Australia. PARTICIPANTS 52 patients undergoing lower limb skin lesion excision. INTERVENTIONS 2 g dose of cephalexin 30-60 min before excision. MAIN OUTCOME MEASURES Incidence of SSI. RESULTS Incidence of SSI was 12.5% (95% CI 2.7% to 32.4%) in the cephalexin group compared with 35.7% (95% CI 18.6% to 55.9%) in the placebo group (p=0.064). This represented an absolute reduction of 23.21% (95% CI -0.39% to 46.82%), relative reduction of 65.00% (95% CI -12.70% to 89.13%) and number-needed-to-treat of 4.3. CONCLUSIONS Administration of a single 2 g dose of cephalexin 30-60 min before skin lesion excision from the lower limb may produce a reduction in the incidence of infection; however, this study was underpowered to statistically determine this. TRIAL REGISTRATION NUMBER ACTRN12611000595910.